An important research focus of this division is to use genomic information to understand disease predisposition, progression and patients' response to drugs. For this, we develop genomic and bioinformatics approaches to identify new biomarkers or candidate drug targets. Our expertise is diverse, spanning from human genetics and functional genomics, to cancer genomics and clinical sequencing. Our main mission is to accelerate the translation of genomic discoveries into the clinic. Members of the division collaborate closely with clinical investigators, in particular via the Clinical and Translational Research Institute.
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The division main areas of research are Genetic and Functional genomics: we identify both rare and common genetic variants that are associated with a variety human diseases. We then annotate these variants, in particular the ones that impact transcriptional regulation, in order to explain their association with the disease.
Cancer Genomics: We look at the molecular profile of tumors of a variety of cancer types to identify novel therapeutic targets, improve disease classification, and understand carcinogenesis and cancer progression. In particular, we develop approaches to integrate both genetic, epigenetic and expression information.
Clinical Sequencing: We develop targeted sequencing technologies and dedicated analysis to accelerate the use of high throughput DNA sequencing in the clinic. For the fist time, physicians can collect information on a large number of clinically actionable mutations in patients and tumor DNA, which helps them provide a better care.